Our Science

The best
of both
Worlds

GenomSys applies its technology expertise in the field of Genomics.

GenomSys contributed decisively to developing the new ISO MPEG-G genomic data standard, the most interoperable and safe technology for genomic data handling today.

We want to enable laboratories to finally experience the full benefits of this new technology standard intuitively without needing to be an IT expert and in a 21st-century manner: cloud-based.

All to take genomic analysis to the next era.

MPEG-G

The Universal Language
for Genomics.

MPEG-G (ISO/IEC 23092) is a series of ISO international standards for the representation of genome sequencing data and associated metadata. The standard MPEG-G aims to provide a framework for developing interoperable applications towards genuinely efficient and economical handling of genomic information and consists of six parts:

Part 1

Transport and Storage
of Genomic Information

Part 1 of the standard deals with data formats for both Transport and Storage of Genomic Information, with reference conversion process and informative annexes. The main topics covered by this part are genomic data streaming and file format.

Part 2

Coding of Genomic Information

Part 2 provides specifications for the normative representation of genomic sequence reads identifiers, genomic sequence reads (both unaligned reads and aligned reads), reference sequences and quality values. This is the part where compression is specified in terms of normative bitstream syntax and decoding behaviour.

Part 3

APIS
and Metadata

Part 3 of the standard specifies information metadata, SAM interoperability, protection metadata and programming interfaces to access genomic information. The main goals are to enable (controlled) access to MPEG-G data from external applications and to add metadata to compressed genomic information.

Part 4

Reference Software 

Part 4 is a support and guide potential implementers of MPEG-G, the standard includes a normative Reference Software. The Reference Software is normative in the sense that any conforming implementation of the decoder, taking the same conformant compressed bitstreams, using the same normative output data structures, will output the same data.

Part 5

Conformance

Conformance testing is fundamental in providing means to validate the correct implementation of the MPEG-G technology in different devices and applications and the interoperability among all systems. This part of the standard specifies a normative procedure to assess conformity to the standard on an exhaustive dataset of compressed data.

Part 6

Alignment

Each part of the standard focuses on one distinct area of the specification to enable more straightforward implementation and testing of compliant devices. New parts can be created to address new needs manifested by the industry during the standard series lifetime.

The Benefits

GenomSys Icon - High Interoperability

Single Unified Syntax

For all genomic-connected file formats (unaligned, aligned, reference, reports,…) to assure the highest data integrity and interoperability included all in one file.

GenomSys Icon - Stronger Security

Built-in Security Elements

Strengthening privacy protection of sensitive individual genomic data: possibility to encrypt natively within the file and grant different access permissions by intervals.

GenomSys Icon - Smaller Files

Efficient Storage Size

Enabling cost savings for organizations handling large volumes of genomic data, particularly for whole-exome and whole-genome datasets decreasing the size by up to 77%.

GenomSys Icon - Rapid Transmission

Rapid Selective Access

MPEG-G enables selecting and decoding individual bases directly from the file without sequentially reading it, resulting in reducing latency running the analysis.

Scientific Progress

Request a License

In our effort to support innovation and the progress of scientific knowledge, GenomSys is ready to provide free of charge Licenses for Development and Implementation Rights, to the extent they are used only for the purpose of experimentation and research with no direct commercial impact. 

Such licenses can only be granted for the IP owned by GenomSys and do not cover any other IP owned by third parties.

A license free of charge for limited time and a limited amount of forfeited royalties will be granted on request.
Contact us to learn more.

Advanced Genomic Analysis

GenomSys is widening the reach of advanced genomic analysis, the basis for any precision medicine application.

Since the development of Next-Generation Sequencing (NGS) technologies, the cost of genome sequencing has been dramatically decreasing and continues to do so at a faster pace than microprocessors’ Moore’s Law. The past few years have hence seen the development of several methodologies and software to analyze the resulting data, however in proprietary formats, requiring transcoding to be processed and often with complex parametrization requirements and control panels.

GenomSys is further developing such tools to work directly with MPEG-G formatted data, reducing pre-processing requirements and increasing efficiency and worldwide applicability. Our pipelines also feature user-friendly and CE certified software applications for parametrization and usage.

We support geneticists in their daily advanced genomic analysis – in a user-friendly manner – paired with state-of-the-art bioinformatic pipelines developed by experts and reliable as well up-to-date annotation databases by Varsome.

Varsome

Genomic Corner

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Genetics, Genomics, or Epigenetics – What is what with DNA and genes? - In our article today on World DNA Day, we want… ... April 25, 2022

Selected projects

Collaborations